Tokelau: a unique low allergen environment at sea level.
نویسندگان
چکیده
BACKGROUND Previous studies have shown that children in Tokelau have a lower prevalence of asthma and atopy compared to Tokelauan children resident in New Zealand. We hypothesized that the low asthma and atopy prevalence in Tokelau may be associated with low indoor allergen levels. METHODS Dust was collected from bedding and floors of 76 homes and four public buildings in Tokelau and from the homes of 30 Tokelauan families in Wellington, New Zealand. Dust samples were analysed for Der p 1, Der f 1, Can f 1, Fel d 1, Bla g 2 and Blo t 5 by ELISA, and for endotoxin by a kinetic amoebocyte lysate assay. RESULTS Der p 1 levels were over 1000-fold lower in Tokelau compared to New Zealand, geometric mean levels were 0.04 and 47.0 microg/g in beds and 0.04 and 44.7 microg/g on floors, respectively. Can f 1 and Fel d 1 levels were also significantly lower in Tokelau. Bed endotoxin levels were significantly higher in Tokelau, geometric mean: 26 736 EU (endotoxin units)/g, compared to 5181 EU/g in New Zealand. Floor endotoxin levels were similar between the two countries. CONCLUSION The very low indoor allergen levels in homes in Tokelau compared to much higher levels in New Zealand homes provides a logical explanation for the lower prevalence of asthma and atopy in Tokelau, compared to New Zealand.
منابع مشابه
Study of Sea Level Variations during Passage of Meteorological Cyclones over the Qeshm Channel
The main purpose of this study is the survey of the atmospheric low pressure effects at sea level oscillations in the Qeshm Channel. For this purpose, the curves of the pressure on the Persian Gulf and Oman Sea, during the passing of the atmospheric low pressure system, are extracted across the region. During the time of occurrence of these events, sea level oscillations in the coastal areas of...
متن کاملBenefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids.
Some patients with severe asthma cannot be controlled with high doses of inhaled steroids (ICS), which may be related to ongoing environmental allergen exposure. We investigated whether 10 weeks of high altitude allergen avoidance leads to sustained benefits regarding clinical and inflammatory markers of disease control in adolescents with persistent asthma despite treatment with high dose ICS....
متن کاملمیانگین گردش جوی منجر به یخبندان های فراگیر در ایران
Introduction According to geographical location of Iran and relatively high elevation of most of its areas above sea-level, occurrence of frosts has many negative effects on different sections, such as agricultural, transportation and energy. Frosts are generally related to displacement and movement of cold anticyclones from northern latitudes to Iran. Wide range of synoptic characteristics is...
متن کاملAssessment of risk from food allergens cross-contamination
Successful food-safety management relies on a clear identification of the hazards to be addressed. In the case of issues relating to food allergens the hazard may be defined as: The inadvertant consumption of a food allergen by a sensitive individual. Ensuring that the risk (probability) of this hazard occuring is maintained at an appropriately low level within the context of modern food-manufa...
متن کاملAnalysis of synoptic - dynamic weather Changes spring precipitation Comprehensive Iran
Introduction: The main feature of Iran's rainfall is their variability; in fact, changes in rainfall are due to changes in their producing factors. The study of rainfall changes in the country showed that the spatial variations of precipitation from west to east and north to south decreased and these changes are well-coordinated with Iran's major rough nesses. The highest rainfall of the southe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
دوره 35 4 شماره
صفحات -
تاریخ انتشار 2005